High-resolution mass spectrometry (HRMS)

High-resolution mass spectrometry (HRMS) is an analytical technique for determining the exact molecular masses of various compounds. The high accuracy makes HRMS ideal for the identification of molecular structures, ranging from small organic molecules to large biological macromolecules.

Sample requirements:

• Information regarding the solubility of the sample in common high-performance liquid chromatography (HPLC) solvents (e.g., H2O, methanol, acetonitrile) or other solvents should be provided.

• 0.1% formic acid is used as an additive in the test. It is essential to confirm the sample's stability in this acid.

• Providing the expected molecular weight of the analyte(s) and molecular structure of the sample as a ChemDraw file is beneficial.

Measurement details:

• Scans can be performed in both positive (+ve) and negative (-ve) ion modes.

• An ACQUITY RDa Detector is utilized for detection.