Testing services / Fragrance allergens in cosmetic products (Regulation (EC) 1223/2009)

Fragrance allergens in cosmetic products (Regulation (EC) 1223/2009)

Analysis of fragrance allergens as specified in Commission Regulation (EC) No 1223/2009 on cosmetic products.

This wide GC-MS/MS screening covers substances added to Annex III of the cosmetic products regulation by Regulation (EC) No 2023/1545, which added dozens of new entries to the allergen list. Some prohibited substances, such as Lilial and Lyral, are also tested for.

The following substances are included in the analysis:

Substance

Reference number in Regulation 1223/2009

Status

Benzyl alcohol

45

Restricted (Annex III)

6-Methyl Coumarin

46

Restricted (Annex III)

Amyl cinnamal

67

Restricted (Annex III)

Cinnamyl alcohol

69

Restricted (Annex III)

Citral, Geranial, Neral

70

Restricted (Annex III)

Eugenol

71

Restricted (Annex III)

Hydroxycitronellal

72

Restricted (Annex III)

Isoeugenol

73

Restricted (Annex III)

Amylcinnamyl alcohol

74

Restricted (Annex III)

Benzyl salicylate

75

Restricted (Annex III)

Cinnamal

76

Restricted (Annex III)

Coumarin

77

Restricted (Annex III)

Geraniol

78

Restricted (Annex III)

Anise alcohol

80

Restricted (Annex III)

Benzyl cinnamate

81

Restricted (Annex III)

Farnesol

82

Restricted (Annex III)

Linalool

84

Restricted (Annex III)

Benzyl benzoate

85

Restricted (Annex III)

Citronellol

86

Restricted (Annex III)

Hexyl cinnamal

87

Restricted (Annex III)

Limonene

88

Restricted (Annex III)

Methyl 2-Octynoate

89

Restricted (Annex III)

alpha-Isomethyl ionone

90

Restricted (Annex III)

Evernia prunastri extract

91

Restricted (Annex III)

Evernia furfuracea extract

92

Restricted (Annex III)

Musk xylene

96

Restricted (Annex III)

Musk ketone

97

Restricted (Annex III)

Methyl eugenol

102

Restricted (Annex III)

Alpha-Terpinene

131

Restricted (Annex III)

Terpinolene

133

Restricted (Annex III)

Acetyl Hexamethyl indan (Phantolide)

134

Restricted (Annex III)

4-tert.- Butyldihydrocinnamaldehyde (Bourgenoal)

155

Restricted (Annex III)

Sum of rose ketones: Alpha-Damascone, cis-Rose ketone 1, trans-Rose ketone 1, Rose ketone 4 (Damascone), Rose ketone 3 (delta-Damascone), trans-Rose ketone 3, cis-Rose ketone 2 (cis-beta-Damascone), trans-Rose ketone 2 (trans-beta-Damascone)

157

Restricted (Annex III)

3-Propylidenephthalide

175

Restricted (Annex III)

Acetyl hexamethyl tetralin (Tonalide)

182

Restricted (Annex III)

Methyl-N-methylanthranilate

323

Restricted (Annex III)

Methyl Salicylate

324

Restricted (Annex III)

Acetyl Cedrene

327

Restricted (Annex III)

Amyl Salicylate

328

Restricted (Annex III)

Anethole (analyzed as trans-Anethole)

329

Restricted (Annex III)

Benzaldehyde

330

Restricted (Annex III)

Camphor

331

Restricted (Annex III)

Beta-Caryo-phyllene

332

Restricted (Annex III)

Carvone

333

Restricted (Annex III)

Dimethyl Phenethyl Acetate (analyzed as Dimethylbenzyl Carbinyl Acetate)

334

Restricted (Annex III)

Hexadecanolactone

335

Restricted (Annex III)

Hexamethylindanopyran

336

Restricted (Annex III)

Linalyl Acetate

337

Restricted (Annex III)

Menthol

338

Restricted (Annex III)

Trimethylcyclopentenyl Methylisopentenol

339

Restricted (Annex III)

Salicylaldehyde

340

Restricted (Annex III)

Santalol (analyzed as alpha-Santalol, beta-Santalol, Santalol (sum of isomers))

341

Restricted (Annex III)

Sclareol

342

Restricted (Annex III)

Terpineol (analyzed as alpha-Terpineol, beta-Terpineol, gamma-Terpineol, Terpineol (sum of isomers))

343

Restricted (Annex III)

Tetramethyl acetyloctahydronaphthalenes

344

Restricted (Annex III)

Trimethylbenzenepropanol

345

Restricted (Annex III)

Vanillin

346

Restricted (Annex III)

Versalide

362

Restricted (Annex III)

Eugenyl Acetate

368

Restricted (Annex III)

Geranyl Acetate

369

Restricted (Annex III)

Isoeugenyl Acetate

370

Restricted (Annex III)

Pinene (analyzed as alpha-Pinene, beta-Pinene, Pinene (sum of isomers))

371

Restricted (Annex III)

Musk Ambrette

414

Prohibited (Annex II)

Moskene

421

Prohibited (Annex II)

Musk Tibetene

422

Prohibited (Annex II)

4-(4-Hydroxy-4-methylpentyl) cyclohex-3-ene1-carbaldehyde (Lyral)

1380

Prohibited (Annex II)

2,6-Dihydroxy-4-methyl-benzaldehyde (atranol)

1381

Prohibited (Annex II)

3-Chloro-2,6-Dihydroxy-4-methyl-benzaldehyde (chloroatranol)

1382

Prohibited (Annex II)

2-(4-tert-butylbenzyl) propionaldehyde (Lilial)

1666

Prohibited (Annex II)

Traseolide (musk fragrance)

-

Not listed

Cashmeran (musk fragrance)

-

Not listed

Celestolid (musk fragrance)

-

Not listed

In most cases, the presence of individual fragrance allergens must be indicated on cosmetics packaging if their concentration exceeds 0.001% in leave-on products or 0.01% in rinse-off products. More detailed restrictions are outlined in annexes to the consolidated version of Regulation (EC) 1223/2009.

Suitable sample matrices
Cosmetics
Required sample quantity
20 g
Typical turnaround time
3 weeks after receiving the samples
Detection limit
5 mg/kg per parameter
Available quality systems
Accredited testing laboratory
Device types
GC-MS/MS
Method expert
Pasi Tuomikoski
Pasi Tuomikoski
CosmeticsCosmeticsCompositional analysisCompositional analysisRegulatory testsRegulatory tests

Price

Typical price (Excl. VAT):
595 €per sample

We also charge a 97 € service fee per order.

Large batches of samples are eligible for discounts.

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