Specific migration testing – primary aromatic amines (PAA), extended package
Primary aromatic amines (PAA) are a class of compounds that are generated when residual isocyanate groups in food contact materials react with the water in foods. In addition, articles in which aniline, benzidine, or other PAAs have been used as precursors for pigments or as curing agents can be a source for restricted PAA.
Certain PAAs are known carcinogens, and these are listed in entry 43 to Appendix 8 of Annex XVII to Regulation (EC) No 1907/2006 of the European Parliament and Council (known as the REACH Regulation). These PAAs are not allowed to migrate into food or food simulants.
Primary aromatic amine testing is especially relevant for products that contain, for example, the following:
Aromatic isocyanate groups containing SML substances
Polyurethane-based materials
Azo dyes
This test package includes the analysis of the following substances:
Substance | CAS number |
2-Amino-4-nitrotoluene | 99-55-8 |
2-Naphthylamine | 91-59-8 |
2,4-Diaminoanisole | 615-05-4 |
2,4-Toluenediamine | 95-80-7 |
2,4,5-Trimethylaniline | 137-17-7 |
3,3'-Dichlorobenzidine | 91-94-1 |
3,3'-Dimethoxybenzidine | 119-90-4 |
4,4ʹ-Diamino-3,3ʹ-dimethyldiphenylmethane, | 838-88-0 |
3,3'-Dimethylbenzidine | 119-93-7 |
4-Aminoazobenzene | 60-09-3 |
4-Aminodiphenyl | 92-67-1 |
4-Chloro-o-toluidine | 95-69-2 |
4,4'-Diaminodiphenylmethane | 101-77-9 |
4,4ʹ-Methylene-bis(2-chloroaniline) | 101-14-4 |
4,4'-Oxydianiline | 101-80-4 |
4,4'-Thiodianiline | 139-65-1 |
Benzidine | 92-87-5 |
o-Aminoazotoluene | 97-56-3 |
o-Anisidine | 90-04-0 |
o-Toluidine | 95-53-4 |
p-Chloroaniline | 106-47-8 |
p-Cresidine | 120-71-8 |
1,2-Phenylenediamine | 95-54-5 |
1,3-Phenylenediamine | 108-45-2 |
1,4-Phenylenediamine | 106-50-3 |
1,5-Diaminonaphthalene | 2243-62-1 |
2-Aminobenzamide | 88-68-6 |
2,4-Dimethylaniline | 95-68-1 |
2,4'-Methylenedianiline | 1208-52-2 |
2,5-Dimethoxy-4-chloroaniline | 6358-64-1 |
2,6-Diaminotoluene | 823-40-5 |
2,6-Dimethylaniline | 87-62-7 |
3-Chloroaniline | 108-42-9 |
4-Aminobenzamide | 2835-68-9 |
4-Methylaminosulfonyl-p-cresidine | 49564-57-0 |
4,4′-Diaminodiphenyl sulfone | 80-08-0 |
5-Amino-6-methyl-2-benzimidazolone | 67014-36-2 |
Aniline | 62-53-3 |
4-Aminotoluene-3-sulfonic acid | 88-44-8 |
N,N-Dimethylaniline | 121-69-7 |
p-Toluidine | 106-49-0 |
Sum of primary aromatic amines | - |
More information about the method family:
LC-MS analysis (LC-MS)- Suitable sample matrices
- Plastic, rubber
- Required sample quantity
- Film: 2xA4-size sheets. Article (< 250 ml): 6 items. Article (> 250 ml): 3 items. Other: 3 dm2
- Typical turnaround time
- 4 weeks after receiving the samples
- Detection limit
- 0.0005 mg/kg
- Available quality systems
- Accredited test method
- Device types
- Standard
- Method expert
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