Testing services / Release of N-nitrosamines and N-nitrosable substances

Release of N-nitrosamines and N-nitrosable substances

Name: Release of N-nitrosamines and N-nitrosable substances
Brand: Measurlabs
SKU: 18876687-98ac-4675-92b2-d9361a1a9f20
Price: 268 EUR
Availability: InStock

N-nitrosamines and N-nitrosatable substances are present, usually in trace quantities, in various environmental media, certain food products, cosmetics, and rubber products. In particular, those found in rubber products are thought to originate from certain additives used in the vulcanization of rubber.

Regulatory reference / standard

Applicable materials

Compliance limits

Applicable reference method

Commission Directive 93/11/EEC

Elastomer or rubber teats and soothers

N-nitrosamines released: 0.01 mg/kg

N-nitrosatable substances released:

0.1 mg/kg

EN 12868

EN 14350

Drinking accessories made of rubber and other elastomers

BfR recommendation XXI/1

Commodities based on natural and synthetic rubber in contact with food

N-nitrosamines: not detected above 1 µg/dm2 (sum of substances)

N-nitrosamines and N-nitrosatable substances are controlled by Commission Directive 93/11/EEC. In addition, recommendation XXI by Germany’s Federal Institute for Risk Assessment (BfR) has set the migration limit of N-nitrosamines from elastomers to food at ≤ 1.0 µg/dm².

The test package covers analysis of the release of the following N-nitrosamines (free and after nitrosation) into artificial saliva simulant or a food simulant:

Substance	Abbreviation	CAS No
N-Nitrosodimethylamine	NDMA	62-75-9
N-Nitrosodi-n-propylamine	NDPA	621-64-7
N-Nitrosodi-n-butylamine	NDBA	924-16-3
N-Nitrosopiperidine	NPIP	100-75-4
N-Nitrosopyrrolidine	NPYR	930-55-2
N-Nitrosomorpholine	NMOR	59-89-2
N-Nitrosobenzylamine	NDBzA	937-32-6
N-Nitrosodi-n-amylamine	NDiNA	2050-92-2
N-Nitroso-methylphenylamine	NMPhA	937-35-9
N-Nitrosoethylphenylamine	NEPhA	612-64-6

More information about the method:

GC-MS analysis TD-GC-MS analysis

Suitable sample matrices: Natural and synthetic rubbers, elastomers
Required sample quantity: 40 g
Typical turnaround time: 3 – 4 weeks after receiving the samples
Detection limit: N-nitrosamines: 0.003 mg/kg; N-nitrosatable substances: 0.003-0.005 mg/kg
Available quality systems: Accredited test method
Device types: GC-MS
Standard: EN 12868 (mod.)EN 14350
Method expert: Niko Markkinen