Zeta potential analysis

Zeta potential, also known as electrokinetic potential, is the difference of the electric potential in the double interface between the surface of a particle and a liquid medium. Zeta potential is used to estimate the stability of colloidal dispersions, which are widely used in various industries, from pharmaceuticals and food to electronics and mineral processing.

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What is zeta potential measurement used for?

Zeta potential measurement can be used to evaluate the stability of colloidal dispersions. Typically, low zeta potential indicates instability - aggregation, coagulation, or flocculation of the particles. Conversely, high zeta potential indicates relative stability, as the particles are unlikely to agglomerate.

What is the zeta potential?

The functional groups on a particle surface will react with the surrounding liquid, which results in a surface charge of the particle. This charge attracts the accumulation of oppositely charged ions and forms a so-called electronic double layer (DL, EDL). The zeta potential is the difference between the dispersion liquid and the DL attached to the particle.

How is it measured?

Electrophoretic light scattering (ELS) is used to measure the electrophoretic mobility of the particles in solutions. The solution is introduced into a cell equipped with electrodes towards which the particles will move more or less rapidly depending on their charge. The mobility is then measured by laser Doppler and converted into zeta potential for direct comparison of materials.

Several factors, including pH, buffer concentration, temperature, and ionic strength, can influence zeta potential.

Suitable sample matrices

  • Nanoparticles
  • Pharmaceuticals
  • Colloids
  • Polymers
  • Emulsions

Ideal uses of zeta potential analysis

  • Determination of the electrokinetic potential of dispersed particles
  • Evaluating the stability of colloidal dispersions

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Frequently asked questions

What is zeta potential analysis commonly used for?

The analysis is used to determine the zeta potential of particles that are dispersed in a liquid medium. This will help evaluate the stability of the particles.

What kind of samples can be analyzed with zeta potential analysis?

Samples can be in a wet or dry state, since samples are dissolved in liquid media prior to analysis.

What is Measurlabs?

Measurlabs offers a variety of laboratory analyses for product developers and quality managers. We perform some of the analyses in our own lab, but mostly we outsource them to carefully selected partner laboratories. This way we can send each sample to the lab that is best suited for the purpose, and offer high-quality analyses with more than a thousand different methods to our clients.

How does the service work?

When you contact us through our contact form or by email, one of our specialists will take ownership of your case and answer your query. You get an offer with all the necessary details about the analysis, and can send your samples to the indicated address. We will then take care of sending your samples to the correct laboratories and write a clear report on the results for you.

How do I send my samples?

Samples are usually delivered to our laboratory via courier. Contact us for further details before sending samples.